Guanidium-functionalized cationic molecular umbrellas as antibacterial agents

Persulfated molecular umbrellas as anti-HIV and anti-HSV agents.

A series of persulfated molecular umbrellas have been synthesized from putrescine, spermidine, spermine, lysine, and cholic acid (1a, 2a, 3a, 4a, and 5a) and their anti-HIV and anti-HSV activities determined. Despite it size, the most active of these conjugates (5a) was able to cross phospholipid bilayers made from 1-palmitoyl-2-oleyol-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl...

Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents.

A series of structurally amphiphilic biscationic norbornanes have been synthesised as rigidified, low molecular weight peptidomimetics of cationic antimicrobial peptides. A variety of charged hydrophilic functionalities were attached to the norbornane scaffold including aminium, guanidinium, imidazolium and pyridinium moieties. Additionally, a range of hydrophobic groups of differing sizes were...

Novel Levofloxacin Derivatives as Potent Antibacterial Agents

In this report, a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against Gram-positive (Bacillus subtillis, Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus) and Gram-negative (Esherichio coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens) organisms. The results showed that some of the synth...

Dendrimers as Antibacterial Agents

Cationic Self-Assembling Peptide Amphiphiles as Antibacterial Agents Against Drug-Resistant Bacteria

Introduction: Bacterial antibiotic resistance has become one of the biggest threats to global health. In the United States alone, at least 2 million cases of illness and 23,000 of deaths are caused by antibioticresistant bacteria annually. The overuse of antibiotics is the most important factor responsible to the development of antibiotic resistance around the world [1]. To overcome bacterial d...